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    Table 2. Its structure is: Both tolterodine and 5-HMT exhibit a high specificity for muscarinic receptors, since both show negligible activity or affinity for other neurotransmitter receptors and other potential cellular targets, such as calcium channels. In the U.

    Adults—At first, 2 milligrams mg two times a day. So much urine builds up in the bladder that it starts leaking out.

    Because these spontaneously reported events are from the worldwide post-marketing experience, the frequency of events and the role of tolterodine in their causation cannot be reliably determined. The active moiety, tolterodine, is a muscarinic receptor antagonist. The main effects of tolterodine at 1 and 5 hours detrol la package insert an increase in residual urine, reflecting an incomplete emptying of the bladder, and a decrease in detrusor pressure.

    After oral administration, tolterodine is metabolized in the liver, resulting in the formation of 5-hydroxymethyl tolterodine 5-HMTthe major pharmacologically active metabolite.

    The partition coefficient Log D between n-octanol and water is 1. A month-old child who ingested 5 to 7 tolterodine immediate release 2 mg tablets was treated with a suspension of activated charcoal and was hospitalized overnight with symptoms of dry mouth. In a study of tolterodine immediate release conducted in cirrhotic patients Child-Pugh Class A and Bthe elimination half-life of tolterodine immediate release was longer in cirrhotic patients mean, 7.

    The child fully recovered or .

    Your doctor will start by asking about your symptoms and medical history, such as any medications you are taking and any operations or procedures you have undergone. This includes prescription or nonprescription over-the-counter [OTC] medicines and herbal or vitamin supplements.

    Ask your healthcare professional how you should dispose of any medicine you do not use. This medicine comes with a patient information insert.

    2.1 Dosing Information

    Table 2. Exposure levels of other metabolites of tolterodine e. In multiple-dose studies in which tolterodine immediate release 4 mg 2 mg bid was administered, serum concentrations of tolterodine and of 5-HMT were similar in healthy elderly volunteers aged 64 through 80 years and healthy young volunteers aged less than 40 years.

    The partition coefficient Log D between n-octanol and water is 1. The change in heart rate with moxifloxacin was 0. Reports of aggravation of symptoms of dementia e.

    The main effects of tolterodine at 1 and 5 hours were an increase in residual urine, reflecting an incomplete emptying of the bladder, and a decrease in detrusor pressure.

    No single QT correction detrol la package insert is known to be more valid than others. The active moiety, tolterodine, is a muscarinic receptor antagonist. The empirical formula of tolterodine tartrate is C26H37NO7. Efficacy was not established in two randomized, placebo-controlled, double-blind, week studies that enrolled pediatric patients on DETROL LA, on placebo aged 5—10 years with urinary frequency and urge incontinence.

    Both the 2 mg and 4 mg capsule strengths are imprinted with a pharmaceutical grade printing ink that contains shellac glaze, titanium dioxide, propylene glycol, and simethicone.

    The pKa value is 9. The child fully recovered.

    A month-old child who ingested 5 to 7 tolterodine immediate release 2 mg tablets was treated with a suspension of activated charcoal and was hospitalized overnight with symptoms of dry mouth Because these spontaneously reported events are from the worldwide post-marketing experience
    After oral administration Both tolterodine and 5-HMT exhibit a high specificity for muscarinic receptors
    Exposure levels of other metabolites of tolterodine e Both the 2 mg and 4 mg capsule strengths are imprinted with a pharmaceutical grade printing ink that contains shellac glaze
    Patients should inform their physician of any other medication or supplement they are taking whether prescription or over-the-counterincluding cyclosporine Efficacy was not established in two randomized
    The empirical formula of tolterodine tartrate is C26H37NO7 Both the 2 mg and 4 mg capsule strengths are imprinted with a pharmaceutical grade printing ink that contains shellac glaze

    Anaphylaxis and angioedema can be life-threatening and require immediate medical attention. Also, do not change your dose without checking first with your doctor. The effects may be increased because of slower removal of the medicine from the body. amalaki tablets benefits.

    Effects on urodynamic parameters before and 1 and 5 hours after a single 6. It is soluble in methanol, slightly soluble in ethanol, and practically insoluble in toluene.

    In multiple-dose studies in which tolterodine immediate release 4 mg 2 mg bid was administered, serum concentrations of tolterodine and of 5-HMT were similar in healthy elderly volunteers aged 64 through 80 years and healthy young volunteers aged less than 40 years.

    Tolterodine tartrate is a white, crystalline powder with a molecular weight of Table 2. QT interval was measured over a hour period following dosing, including the time of peak plasma concentration Tmax of tolterodine and at steady state Day 4 of dosing.

    A month-old child who ingested 5 to 7 tolterodine immediate release 2 mg tablets was treated with a suspension of activated charcoal and was hospitalized overnight with symptoms of dry mouth. A month-old child who ingested 5 to 7 tolterodine immediate release 2 mg tablets was treated with a detrol la package insert of activated charcoal and was hospitalized overnight with symptoms of dry mouth.

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