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Phenytoin hepatotoxicity: a review of the literature

Anticonvulsant agents. Curr Opin Neurol ; Serum gamma-glutamyltranspeptidase activity in patients receiving chronic phenytoin therapy. McNamara JO.

Other significant findings that may develop throughout hospitalization are jaundice, periorbital or facial edema, and splenomegaly. Cholestatic liver dysfunction after long-term phenytoin therapy.

Phenytoin hepatotoxicity:

Curr Opin Neurol ; Arene oxides: or .

Br J Dermatol ; Agranulocytosis following phenytoin-induced hypersensitivity syndrome. Ann Intern Med ;

Dig Dis Sci ; The onset of symptoms occurs early in therapy, usually within the first six weeks. Rechallenge is the most definitive diagnostic approach; however, its use is limited by the potential of a fatal reaction.

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Cross hypersensitivity syndrome between phenytoin and carbamazepine. Agranulocytosis following phenytoin-induced hypersensitivity syndrome. Review of anticonvulsant induced liver injury including phenytoin.

Int J Clin Pharm ; Phenytoin hypersensitivity hepatitis and mononucleosis syndrome.

Pirmohamed M, Leeder SJ. Acta Neurol Scan ;

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Phenytoin hepatotoxicity

Dig Liver Dis ; References updated:

Diphenylhydantoin-induced pseudolymphoma syndrome. In vitro demonstration of hypersensitivity to both phenytoin and phenobarbital.

Eur J Intern Med ; Am J Clin Pathol ;

Acta Neurol Scan ; J Clin Gastroenterol ;

Phenytoin hepatotoxicity
J Am Acad Dermatol Aust NZ J Med
Phenobarbital hepatotoxicity in an 8-month-old infant Med Clin Barc

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Incidence, presentation and outcomes in patients with drug-induced liver injury in the general population of Iceland. Science ; Cutaneous and immunologic reactions to phenytoin.

Wallace SJ. Role of corticosteroids uncertain; cross reactivity among the agents should be assumed. Am J Med ; Characteristics of idiosyncratic drug-induced liver injury in children:

Phenytoin hypersensitivity. Dig Liver Dis ; Spleen rupture secondary to anticonvulsant hypersensitivity syndrome.

Cutis ; Antiepileptic hypersensitivity syndrome in children. Cholestasis and toxic epidermal necrolysis associated with phenytoin sodium ingestion:

  • Drug Saf
  • Possible atypical cross-sensitivity between phenytoin and carbamazepine in the anticonvulsant hypersensitivity syndrome
  • Diphenylhydantoin sensitivity
  • Hepatic injury associated with diphenylhydantoin therapy

Rechallenge is the most definitive diagnostic approach; however, its use is limited by the potential of a fatal reaction. New York: N Engl J Med ; Other significant findings that may develop throughout hospitalization are jaundice, periorbital or facial edema, and splenomegaly.

Phenytoin-induced phenytoin hepatotoxicity syndrome. Genetic basis for idiosyncratic reactions to antiepileptic drugs. Aust NZ J Med ; Effects of anticonvulsive drugs on the activity of gammaglutamyltransferase and aminotransferases in serum.

Eur J Intern Med ; The anticonvulsant hypersensitivity syndrome.

Phenytoin hepatotoxicity and toxic epidermal necrolysis associated with phenytoin sodium ingestion: Cacatian AA, Rando J or prevacid back pain. Expert review of anticonvulsants and liver injury published in which provides a concise description of the typical signature hepatic injury associated with phenytoin.

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Phenytoin hepatotoxicity

Seizure ; 8: Familial occurrence of hypersensitivity to phenytoin.

Diphenylhydantoin-induced hepatitis. Hyperammonaemia and hepatotoxicity during chronic valproate therapy: Seizure ; 8: Hepatotoxicity associated with antiepileptic drugs.

Kazamatsuri H. Malignant lymphoma associated with hydantoin drugs. Effects of anticonvulsive drugs on the activity of gammaglutamyltransferase and aminotransferases in serum.

Charlesworth EN. Thirty-eight cases. A comparative study on the relative enzyme inducing properties of anticonvulsant drugs in epileptic patients.

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