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Despite their clinical efficacy, once-daily administration of conventional single-release PPIs does not always adequately control intragastric acidity over a hour period in a significant proportion of GERD patients, leading to suboptimal symptom relief, particularly at night. Because there are millions of parietal cells that are constantly reproducing, complete inhibition of stomach acid production is virtually impossible. Nexium esomeprazole gives you long-lasting heartburn relief but has some risks if used long term. But then I noticed I was constipated and had a huge appetite.
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